Date: November 2021.
Source: Autism Research (official journal of INSAR), Volume 14, Issue 11, Pages 2260-2269.
Abstract: Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the ‘broad autism phenotype’. Therefore, the aim of the current study was to examine whether a broad autism phenotype expresses as facial asymmetry among 192 biological parents of autistic individuals (134 mothers) compared to those of 163 age-matched adults without a family history of ASD (113 females). Using dense surface-modelling techniques on three dimensional facial images, we found evidence for greater facial asymmetry in parents of autistic individuals compared to age-matched adults in the comparison group (p = 0.046, d = 0.21 [0.002, 0.42]). Considering previous findings and the current results, we conclude that facial asymmetry expressed in the facial morphology of autistic children may be related to heritability factors.

Article: Facial asymmetry in parents of children on the autism spectrum.
Authors: Diana Weiting Tan, Syed Zulqarnain Gilani, Maryam Boutrus, Gail A Alvares, Andrew JO Whitehouse, Ajmal Mian, David Suter, Murray T Maybery. The University of Western Australia, Perth, Western Australia, Australia