Genetics of the human face: Identification of large-effect single gene variants. DJM Crouch, B Winney, WP Koppen, WJ Christmas, K Hutnik, T Day, D Meena, A Boumertit, P Hysi, A Nessa, TD Spector, J Kittler, WF Bodmer.

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Date: October 2017 Source: PNAS | Proceedings of the National Academy of Sciences of the United States of America, doi: 10.1073/pnas.1708207114. Significance: The human face is extraordinarily variable, and the extreme similarity of the faces of identical twins indicates that most of this variability is genetically determined. We have devised an approach to increase the…

Evaluation of Head Position in Static and Dynamic Three-Dimensional Imaging: a review of the Literature. M Kjærgaard Larsen, TH Thygesen.

3dMD Customer Research, Dental, Genetics, Medical, 3dMDface, Craniofacial/Cleft, Oral and Maxillofacial, Orthodontics, Orthognathic, Plastics, 3dMDface System

Date: August 2017. Source: International Journal of Oral and Craniofacial Science, 3(2), pp 34-38. Background: : The interest in three-dimensional imaging in orthognathic treatment planning has been growing, especially for evaluation of the natural head position. Several three-dimensional devices are available on the market. Three-dimensional evaluation of the patient will probably soon be a standard…

Hypermasculinised facial morphology in boys and girls with Autism Spectrum Disorder and its association with symptomatology. DW Tan, SZ Gilani, MT Maybery, A Mian, A Hunt, M Walters, AJO Whitehouse.

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Date: August 2017 Source: nature.com SCiENtifiC REporTS | 7: 9348 Abstract: Elevated prenatal testosterone exposure has been associated with Autism Spectrum Disorder (ASD) and facial masculinity. By employing three-dimensional (3D) photogrammetry, the current study investigated whether prepubescent boys and girls with ASD present increased facial masculinity compared to typically-developing controls. There were two phases to…

A Phenotypically Driven Segmentation for 3-D Facial Morphology: Modularity of 3-D Faces Through Spectral Clustering. D SERO, D VANDERMEULEN, P CLAES.

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Date: June 2017 Source: Biological Shape Analysis: Proceedings of the 4th International Symposium (ISBSA), pp 249-258. School of Dentistry, UCLA, USA, 19–22 June 2015. Abstract: Facial morphology is the result of mazy interactions between environmental and epigenetic factors that lead to the composition of multiple subunits integrated to function as a whole. In this work, we…

THREE-DIMENSIONAL EVALUATION OF CLASS III TREATMENT OF A 6 YEAR OLD BOY WITH THE FRÄNKEL FUNCTION REGULATOR III MODIFIED APPLIANCE. BK Đokić, A Zhurov, S Richmond, M Ovsenik.

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Date: June 2017. Source: 93rd Congress of the European Orthodontic Society 2017. Montreux, Switzerland. Aim: To objectively demonstrate the changes of soft tissues after use of a Fränkel functional regulator III (FFR III) modified appliance (Farčnik, 2008) of a skeletal Class III malocclusion Subject and Methods: Clinical examination of the 6 year old boy revealed…

Association Between Prenatal Alcohol Exposure and Craniofacial Shape of Children at 12 Months of Age. E Muggli, H Matthews, A Penington, et al.

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Date: June 2017 (Online). Source: JAMA Pediatrics, doi:10.1001/jamapediatrics.2017.0778. Question: Is there an association between different levels of prenatal alcohol exposure and child craniofacial shape at 12 months? Findings: This cohort study conducted an objective and sensitive craniofacial phenotype analysis of 415 children, which showed an association between prenatal alcohol exposure and craniofacial shape at almost…

The Effects of Objective 3D Measures of Facial Shape and Symmetry on Perceptions of Facial Attractiveness. CD Hatch, GL Wehby, NL Nidey, LM Moreno Uribe.

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Date: May 2017 Source: Journal of Oral and Maxillofacial Surgery. Purpose: Meeting patient desires for enhanced facial esthetics requires that providers have standardized and objective methods to measure esthetics. We evaluated the effects of objective 3-dimensional (3D) facial shape and asymmetry measurements derived from 3D facial images on perceptions of facial attractiveness. Patient and Methods:…

Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2. MK Lee, JR Shaffer JR, EJ Leslie, E Orlova, JC Carlson, E Feingold, ML Marazita, SM Weinberg.

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Date: April 2017. Source: PLoS One. 12(4): e0176566. Abstract: Several studies have now shown evidence of association between common genetic variants and quantitative facial traits in humans. The reported associations generally involve simple univariate measures and likely represent only a small fraction of the genetic loci influencing facial morphology. In this study, we applied factor…

A predictive model for obstructive sleep apnea and Down syndrome. BG Skotko et al.

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Date: January 2017. Source: American Journal of Medical Genetics. Abstract: Obstructive sleep apnea (OSA) occurs frequently in people with Down syndrome (DS) with reported prevalences ranging between 55% and 97%, compared to 1–4% in the neurotypical pediatric population. Sleep studies are often uncomfortable, costly, and poorly tolerated by individuals with DS. The objective of this…

The 3D Facial Norms Database: Part 1. A Web-Based Craniofacial Anthropometric and Image Repository for the Clinical and Research Community.

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Date: November 2016. Source: Cleft Palate Craniofacial Journal, 53(6) pp. e185–e197. Background: Although craniofacial sex differences have been extensively studied in humans, relatively little is known about when various dimorphic features manifest during postnatal life. Using cross-sectional data derived from the 3D Facial Norms data repository, we tested for sexual dimorphism of craniofacial soft-tissue morphology…