A new method for three-dimensional evaluation of the cranial shape and the automatic identification of craniosynostosis using 3D stereophotogrammetry. JW Meulstee1, LM Verhamme, WA Borstlap, F Van der Heijden, GA De Jong, T Xi, SJ Bergé, H Delye, TJJ Maal.

Date: April 2017 (Online). Source: International Journal of Oral and Maxillofacial Surgery. Abstract: Craniosynostosis is a congenital defect which can result in abnormal cranial morphology. Three dimensional (3D) stereophotogrammetry is potentially an ideal technique for the evaluation of cranial morphology and diagnosis of craniosynostosis because it is fast and harmless. This study presents a new…

Investigating the case of human nose shape and climate adaptation. AA Zaidi , BC Mattern, P Claes, B McEcoy, C Hughes, MD Shriver.

Date: March 2017. Source: PLoS Genetics 13(3): e1006616. Abstract: The evolutionary reasons for variation in nose shape across human populations have been subject to continuing debate. An import function of the nose and nasal cavity is to condition inspired air before it reaches the lower respiratory tract. For this reason, it is thought the observed…

A predictive model for obstructive sleep apnea and Down syndrome. BG Skotko et al.

Date: January 2017. Source: American Journal of Medical Genetics. Abstract: Obstructive sleep apnea (OSA) occurs frequently in people with Down syndrome (DS) with reported prevalences ranging between 55% and 97%, compared to 1–4% in the neurotypical pediatric population. Sleep studies are often uncomfortable, costly, and poorly tolerated by individuals with DS. The objective of this…

A comparison of soft tissue topographical norms for the local ethnic people of Zimbabwe and African American norms based on 3dMD soft tissue photography. E Bhaskar.

Date: December 2016. Source: Master of Science Thesis, The University of Alabama at Birmingham. Introduction: The purpose of this study is to determine the soft tissue topographical norms for the local ethnic people of Zimbabwe and compare them with the African American norms based on 3dMD soft tissue photography. The rationale for the study is…

The 3D Facial Norms Database: Part 1. A Web-Based Craniofacial Anthropometric and Image Repository for the Clinical and Research Community.

Date: November 2016. Source: Cleft Palate Craniofacial Journal, 53(6) pp. e185–e197. Background: Although craniofacial sex differences have been extensively studied in humans, relatively little is known about when various dimorphic features manifest during postnatal life. Using cross-sectional data derived from the 3D Facial Norms data repository, we tested for sexual dimorphism of craniofacial soft-tissue morphology…

The course of positional cranial deformation from 3 to 12 months of age and associated risk factors: a follow-up with 3D imaging. H Aarnivala, V Vuollo, V Harila, T Heikkinen, P Pirttiniemi, L Holmström, AM Valkama.

Date: September 2016. Source: European Journal of Pediatrics, pp 1–11. doi:10.1007/s00431-016-2773-z. Abstract: Deformational plagiocephaly is reported in up to 46.6 % of healthy infants, with the highest point prevalence at around 3 months of age. Few prospective studies on the natural course of skull deformation have been conducted, and we know of no studies using…

Genetic and Environmental Contributions to Facial Morphological Variation: A 3D Population-Based Twin Study. J Djordjevic, AI Zhurov, S Richmond, Visigen Consortium.

Date: September 2016 Source: PLoS One. 11(9):e0162250. Introduction: Facial phenotype is influenced by genes and environment; however, little is known about their relative contributions to normal facial morphology. The aim of this study was to assess the relative genetic and environmental contributions to facial morphological variation using a three-dimensional (3D) population-based approach and the classical…

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. JR Shaffer, E Orlova, MK Lee, EJ Leslie, ZD Raffensperger, CL Heike, more…

Date: August 2016 Source: PLOS Genetics Abstract: Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide association meta-analyses of 20 quantitative facial measurements derived from the 3D surface…

Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping. D Tsagkrasoulis, P Hysi, T Spector, G Montana.

Date: August 2016 Source: ResearchGate Abstract: The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability estimates of facial traits have often been surprisingly low or difficult to replicate. Furthermore, the construction of facial phenotypes that correspond to naturally perceived facial features remains…

Multiscale Mechano-Biological Finite Element Modelling of Oncoplastic Breast Surgery—Numerical Study towards Surgical Planning and Cosmetic Outcome Prediction. Vavourakis V, Eiben B, Hipwell JH, Williams NR, Keshtgar M, Hawkes DJ.

Date: July 2016 Source: PLoS ONE 11(7): e0159766. Abstract: Surgical treatment for early-stage breast carcinoma primarily necessitates breast conserving therapy (BCT), where the tumour is removed while preserving the breast shape. To date, there have been very few attempts to develop accurate and efficient computational tools that could be used in the clinical environment for…