Measuring Symmetry in Children With Cleft Lip. Part 3: Quantifying Nasal Symmetry and Nasal Normalcy Before and After Unilateral Cleft Lip Repair. S Liang, L Shapiro, R Tse.

Date: October 2016 (Online). Source: The Cleft Palate-Craniofacial Journal. Objective: The purpose of this project was to develop objective computer-based methods to measure nasal asymmetry and abnormality in children undergoing treatment of unilateral cleft lip (UCL) and to determine the correlation of these measures to clinical expectations. Participants: Thirty infants with UCL undergoing cleft lip…

Three-dimensional stereophotogrammetry as an accurate tool in analysis of lymphedema of the hand. IA Hoevenaren, AC Verhulst, M Hameeteman, RD Vreeken, TJJ Maal, DJO Ulrich.

Date: September 2016 (Online). Source: Journal of Plastic, Reconstructive and Aesthetic Surgery. Background: Lymphedema of the upper extremity is a frequently seen manifestation after breast cancer surgery. Three-dimensional (3D) stereophotogrammetry is a reliable technique in clinical practice, for example in volume measurements. The purpose of this research was to investigate if 3D imaging could be…

Quantification of facial asymmetry: A comparative study of landmark-based and surface-based registrations. T Verhoeven, T Xic, R Schreurs, S Bergé, TJJ Maal.

Date: September 2016. Source: Journal of Cranio-Maxillo-Facial Surgery, Volume 44, Issue 9, Pages 1131–1136. Objective: To compare the validity and reproducibility of four different methods for the quantification of soft tissue facial asymmetry. Methods: Twenty 3D-photographs were randomly selected from the healthy control database. To assess the validity of the one landmark-based and three surface-based…

Genetic and Environmental Contributions to Facial Morphological Variation: A 3D Population-Based Twin Study. J Djordjevic, AI Zhurov, S Richmond, Visigen Consortium.

Date: September 2016 Source: PLoS One. 11(9):e0162250. Introduction: Facial phenotype is influenced by genes and environment; however, little is known about their relative contributions to normal facial morphology. The aim of this study was to assess the relative genetic and environmental contributions to facial morphological variation using a three-dimensional (3D) population-based approach and the classical…

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. JR Shaffer, E Orlova, MK Lee, EJ Leslie, ZD Raffensperger, CL Heike, more…

Date: August 2016 Source: PLOS Genetics Abstract: Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide association meta-analyses of 20 quantitative facial measurements derived from the 3D surface…

Endoscopically assisted craniosynostosis surgery (EACS): The craniofacial team Nijmegen experience. HHK Delye, S Arts, WA Borstlap, LM Blok, JJ Driessen, JW Meulstee, TJJ Maal, EJ van Lindert

Date: August 2016 Source: Journal of Cranio-Maxillo-Facial Surgery. Volume 44, Issue 8, Pages 1029–1036. Introduction: An evaluation of our first 111 consecutive cases of non-syndromic endoscopically assisted craniosynostosis surgery (EACS) followed by helmet therapy. Methods: Retrospective analysis of a prospective registration database was performed. Age, duration of surgery, length of hospital stay, blood loss, transfusion…

Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping. D Tsagkrasoulis, P Hysi, T Spector, G Montana.

Date: August 2016 Source: ResearchGate Abstract: The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability estimates of facial traits have often been surprisingly low or difficult to replicate. Furthermore, the construction of facial phenotypes that correspond to naturally perceived facial features remains…

Multiscale Mechano-Biological Finite Element Modelling of Oncoplastic Breast Surgery—Numerical Study towards Surgical Planning and Cosmetic Outcome Prediction. Vavourakis V, Eiben B, Hipwell JH, Williams NR, Keshtgar M, Hawkes DJ.

Date: July 2016 Source: PLoS ONE 11(7): e0159766. Abstract: Surgical treatment for early-stage breast carcinoma primarily necessitates breast conserving therapy (BCT), where the tumour is removed while preserving the breast shape. To date, there have been very few attempts to develop accurate and efficient computational tools that could be used in the clinical environment for…

New expert panel hoping to unlock mysteries of undiagnosed diseases.

Date: 23 Jul 2016, 10:23p Source: ABC News Australia Author: Claire Moodie Jessica’s mystery disease tackled by expert panel The family of a Perth girl is cautiously hoping a panel of experts will be able to diagnose the mystery condition which has baffled the 11-year-old’s doctors for years. 190,000 West Australians affected by rare diseases.…